Category Archives: Publications

Older publications

Older publications:

Substrate discrimination by cholapod anion receptors: Geometric effects and the “affinity-selectivity principle”. J. P. Clare, A. J. Ayling, J. B. Joos, A. L. Sisson, G. Magro, M. N. Perez-Payan, T. N. Lambert, R. Shukla, B. D. Smith, A. P. Davis, J. Am. Chem. Soc. 2005, 127, 10739.

Organogel media for on-bead screening in combinatorial catalysis. K. J. Johansson, M. R. M. Andreae, A. Berkessel, A. P. Davis, Tetrahedron Lett. 2005, 46, 3923.

A short synthesis of methyl 3 alpha,7 alpha,12 alpha triaminocholanoate, the ‘triaza-analogue’ of methyl cholate. V. del Amo, K. Bhattarai, M. Nissinen, K. Rissanen, M. N. Perez-Payan, A. P. Davis, Synlett 2005, 1319.

Carbohydrate receptors. A. P. Davis, T. D. James, in Functional Synthetic Receptors (Eds.: T. Schrader, A. D. Hamilton), Wiley-VCH, Weinheim, 2005, p. 45 – 109.

A fluorescent assay for chloride transport; identification of a synthetic anionophore with improved activity. B. A. McNally, A. V. Koulov, B. D. Smith, J. B. Joos, A. P. Davis, Chem. Commun. 2005, 1087.

Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate. T. Gunnlaugsson, A. P. Davis, J. E. O’Brien, M. Glynn, Org. Biomol. Chem. 2005, 3, 48.

A blue dye for substrate tagging in the two-color screening of combinatorial libraries. V. del Amo, A. P. McGlone, C. Foster, A. P. Davis, J. Comb. Chem. 2005, 7, 1.

Carbohydrate Recognition in Water by a Tricyclic Polyamide Receptor. E. Klein, M. P. Crump, A. P. Davis, Angew. Chem. Int. Ed. 2005, 44, 298.

Differentially-Protected Steroidal Triamines; Scaffolds with Potential for Medicinal, Supramolecular, and Combinatorial Chemistry. V. del Amo, L. Siracusa, T. Markidis, B. Baragaña, K. M. Bhattarai, M. Galobardes, G. Naredo, M. N. Pérez-Payán, A. P. Davis, Org. Biomol. Chem. 2004, 2, 3320.

Electrochemical Quantification of High-Affinity Halide Binding by a Steroid-Based Receptor. R. A. W. Dryfe, S. S. Hill, A. P. Davis, J.-B. Joos, E. P. L. Roberts, A. C. Fisher, Org. Biomol. Chem. 2004, 2, 2716.

Design, synthesis and photophysical studies of simple fluorescent anion PET sensors using charge neutral thiourea receptors. T. Gunnlaugsson, A. P. Davis, G. M. Hussey, J. Tierney, M. Glynn, Org. Biomol. Chem. 2004, 2, 1856.

Steroid-Based Anion Complexation Agents. A. P. Davis, in Encyclopedia of Supramolecular Chemistry (Eds.: J. L. Attwood, J. W. Steed), Marcel Dekker, New York, 2004, p. 236.

Chiral Guest Recognition. A. P. Davis, in Encyclopedia of Supramolecular Chemistry (Eds.: J. L. Attwood, J. W. Steed), Marcel Dekker, New York, 2004, p. 1365.

Phase Transfer of Monosaccharides Through Noncovalent Interactions. E. K. Auty, A. P. Davis, in Dekker Encyclopedia of Nanoscience and Nanotechnology (Eds.: J. A. Schwarz, C. I. Contescu, K. Putyera), Marcel Dekker, New York, 2004, p. 2825.

Tuning selectivity in macrotricyclic carbohydrate receptors; CH -> N mutations in aromatic spacers. T. Velasco, G. Lecollinet, T. Ryan, A. P. Davis, Org. Biomol. Chem. 2004, 2, 645.

Chloride transport across vesicle and cell membranes by steroid-based receptors. A. V. Koulov, T. N. Lambert, R. Shukla, M. Jain, J. M. Boon, B. D. Smith, H. Y. Li, D. N. Sheppard, J. B. Joos, J. P. Clare, A. P. Davis, Angew. Chem. Int. Ed. 2003, 42, 4931.

Perturbing the Hofmeister series: a steroid-based anion receptor with preorganised quaternary ammonium and H-bond donor groups. A. L. Sisson, J. P. Clare, L. H. Taylor, J. P. H. Charmant, A. P. Davis, Chem. Commun. 2003, 2246.

Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase. J. M. Boon, T. N. Lambert, A. L. Sisson, A. P. Davis, B. D. Smith, J. Am. Chem. Soc. 2003, 125, 8195.

Steroids as organising elements in anion receptors. A. P. Davis, J.-B. Joos, Coord. Chem. Rev. 2003, 240, 143.

Evaluation of a two-stage screening procedure in the combinatorial search for serine protease-like activity. A. Madder, L. Li, H. De Muynck, N. Farcy, D. Van Haver, F. Fant, G. Vanhoenacker, P. Sandra, A. P. Davis, P. J. De Clercq, J. Comb. Chem. 2002, 4, 552.

Steroidal ureas as enantioselective receptors for an N-acetyl alpha-amino carboxylate. L. Siracusa, F. M. Hurley, S. Dresen, L. J. Lawless, M. N. Perez-Payan, A. P. Davis, Org. Lett. 2002, 4, 4639.

Highly selective disaccharide recognition by a tricyclic octaamide cage. G. Lecollinet, A. P. Dominey, T. Velasco, A. P. Davis, Angew. Chem. Int. Ed. 2002, 41, 4093.

Fluorescent sensing of pyrophosphate and bis-carboxylates with charge neutral PET chemosensors. T. Gunnlaugsson, A. P. Davis, J. E. O’Brien, M. Glynn, Org. Lett.2002, 4, 2449.

Enantioselective transport by a steroidal guanidinium receptor. B. Baragana, A. G. Blackburn, P. Breccia, A. P. Davis, J. de Mendoza, J. M. Padron-Carrillo, P. Prados, J. Riedner, J. G. de Vries, Chem. Eur. J. 2002, 8, 2931.

Facilitated phospholipid flip-flop using synthetic steroid- derived translocases. T. N. Lambert, J. M. Boon, B. D. Smith, M. N. Perez-Payan, A. P. Davis, J. Am. Chem. Soc. 2002, 124, 5276.

An extraction-based assay for neutral anionophores: The measurement of high binding constants to steroidal receptors in a nonpolar solvent. A. J. Ayling, S. Broderick, J. P. Clare, A. P. Davis, M. N. Perez-Payan, M. Lahtinen, M. J. Nissinen, K. Rissanen, Chem. Eur. J. 2002, 8, 2197.

Phase Transfer of Monosaccharides Through Non-Covalent Interactions; Selective Extraction of Glucose by a Lipophilic Cage Receptor. T. J. Ryan, G. Lecollinet, T. Velasco, A. P. Davis, Proc. Natl. Acad. Sci. USA 2002, 99, 4863.

Fluorescent photoinduced electron transfer (PET) sensing of anions using charge neutral chemosensors. T. Gunnlaugsson, A. P. Davis, M. Glynn, Chem. Commun.2001, 2556.

New “cholapod” anionophores; high-affinity halide receptors derived from cholic acid. A. J. Ayling, M. N. Perez-Payan, A. P. Davis, J. Am. Chem. Soc. 2001, 123, 12716.

A new screen for combinatorial catalysis; On-bead testing in agarose gel. M. Muller, T. W. Mathers, A. P. Davis, Angew. Chem. Int. Ed. 2001, 40, 3813.

Gel-phase MAS NMR spectroscopy of a polymer-supported pseudorotaxane and rotaxane: Receptor binding to an “inert” polyethylene glycol spacer. Y. F. Ng, J.-C. Meillon, T. Ryan, A. P. Dominey, A. P. Davis, J. K. M. Sanders, Angew. Chem. Int. Ed. 2001, 40, 1757.

Steroidal guanidines as enantioselective receptors for N-acyl alpha-amino acids. Part 1. 3 alpha-Guanylated carbamates derived from cholic acid. L. J. Lawless, A. G. Blackburn, A. J. Ayling, M. N. Perez-Payan, A. P. Davis, J. Chem. Soc. Perkin Trans. 1 2001, 1329.

Non-leaky vesicle fusion and enhanced cell transfection using a cationic facial amphiphile. Y. R. Vandenburg, B. D. Smith, M. N. Perez-Payan, A. P. Davis, J. Am. Chem. Soc. 2000, 122, 3252.

Application of combinatorial procedures in the search for serine-protease-like activity with focus on the acyl transfer step. H. De Muynck, A. Madder, N. Farcy, P. J. De Clercq, M. N. Perez-Payan, L. M. Ohberg, A. P. Davis, Angew. Chem. Int. Ed. 2000, 39, 145.

A novel sensitive colorimetric assay for visual detection of solid-phase bound amines. A. Madder, N. Farcy, N. G. C. Hosten, H. De Muynck, P. J. De Clercq, J. Barry, A. P. Davis, Eur. J. Org. Chem. 1999, 2787.

The N-carbamoyl squaramide dimer: a compact, strongly associated H-bonding motif. A. P. Davis, S. M. Draper, G. Dunne, P. Ashton, Chem. Commun. 1999, 2265.

Carbohydrate recognition through noncovalent interactions: A challenge for biomimetic and supramolecular chemistry. A. P. Davis, R. S. Wareham, Angew. Chem. Int. Ed. 1999, 38, 2978.

Synthetic molecular motors. A. P. Davis, Nature 1999, 401, 120.

The “triamino-analogue” of methyl cholate; A practical, large- scale synthesis. A. P. Davis, M. N. Perez-Payan, Synlett 1999, 991.

A trifunctional steroid-based scaffold for combinatorial chemistry. J. F. Barry, A. P. Davis, M. N. Perez-Payan, M. R. J. Elsegood, R. F. W. Jackson, C. Gennari, U. Piarulli, M. Gude, Tetrahedron Lett. 1999, 40, 2849.

Steroidal guanidinium receptors for the enantioselective recognition of N-acyl alpha-amino acids. A. P. Davis, L. J. Lawless, Chem. Commun. 1999, 9.

A tricyclic polyamide receptor for carbohydrates in organic media. A. P. Davis, R. S. Wareham, Angew. Chem. Int. Ed. 1998, 37, 2270.

The triisopropylsilyl effect: exceptional Cram-type selectivity in Mukaiyama aldol reactions of a silyl ketene thioacetal. A. P. Davis, S. J. Plunkett, J. E. Muir, Chem. Commun. 1998, 1797.

The “Triamino-analogue” of Methyl Cholate; A Facial Amphiphile and Scaffold with Potential for Combinatorial and Molecular Recognition Chemistry. S. Broderick, A. P. Davis, R. P. Williams, Tetrahedron Lett. 1998, 39, 6083.

Anion recognition by alkyl cholates: Neutral anionophores closely related to a natural product. A. P. Davis, J. J. Perry, R. S. Wareham, Tetrahedron Lett. 1998, 39, 4569.

Tilting at windmills? The second law survives. A. P. Davis, Angew. Chem. Int. Ed. Engl. 1998, 37, 909.

A new generation of ”cholaphanes”: Steroid-derived macrocyclic hosts with enhanced solubility and controlled flexibility. K. M. Bhattarai, A. P. Davis, J. J. Perry, C. J. Walter, S. Menzer, D. J. Williams, J. Org. Chem. 1997, 62, 8463.

Mitsunobu reactions with methanesulfonic acid; The replacement of equatorial hydroxyl groups by azide with net retention of configuration. A. P. Davis, S. Dresen, L. J. Lawless, Tetrahedron Lett. 1997, 38, 4305.

Deracemization by enantiodifferentiating inversion in 1,3-diols. A. P. Davis, Angew. Chem. Int. Ed. Engl. 1997, 36, 591.

Anion recognition by tripodal receptors derived from cholic acid. A. P. Davis, J. J. Perry, R. P. Williams, J. Am. Chem. Soc. 1997, 119, 1793.

Supersilylating agents from chlorosilanes. A. P. Davis, J. E. Muir, S. J. Plunkett, Tetrahedron Lett. 1996, 37, 9401..

A steroid-based cryptand for halide anions. A. P. Davis, J. F. Gilmer, J. J. Perry, Angew. Chem. Int. Ed. Engl. 1996, 35, 1312.

Steroid-based receptors with tunable cavities; A series of polyhydroxylated macrocycles of varying size and flexibility. A. P. Davis, S. Menzer, J. J. Walsh, D. J. Williams, Chem. Commun. 1996, 453.

Steroid-based receptors with tunable cavities; Stepwise and direct syntheses of a C-3-symmetrical prototype. A. P. Davis, J. J. Walsh, Chem. Commun. 1996, 449.

Synthesis and investigation of a hindered chiral bicyclic guanidine. A. P. Davis, K. J. Dempsey, Tetrahedron: Asymmetry 1995, 6, 2829.

Synthesis of (S)-2-Amino-1,1-diphenylbutan-4-ol; Conversion of an a-Amino Acid into an a-(Diphenylmethyl) Amine Without Loss of Optical Purity. P. H. Boyle, A. P. Davis, K. J. Dempsey, G. D. Hosken, Tetrahedron: Asymmetry 1995, 6, 2819.

Reagent Control of Cram-Type Selectivity in the Mukaiyama Aldol Catalyzed by Supersilylating Agents. A. P. Davis, S. J. Plunkett, J. Chem. Soc. Chem. Commun.1995, 2173.

Antimony-Based “Forcing Knoevenagel” Methodology for the Conversion of Ketones into Alkylidenemalonates. A. P. Davis, K. M. Bhattarai, Tetrahedron 1995, 51, 8033.

Synthesis and Properties of Enantiopure Bicyclic Amidines. M. A. Convery, A. P. Davis, C. J. Dunne, J. W. MacKinnon, Tetrahedron Lett. 1995, 36, 4279.

1,1,3,3-Tetraethyl-1,3-disilaisoindolines; Chromatographically Stable Silicon-Based Protection for Primary Amines. A. P. Davis, P. J. Gallagher, Tetrahedron Lett.1995, 36, 3269.

6-Phenylsulphonyl-2,10-diazabicyclo[4.4.0]dec-1-ene; A Readily Accessible, Prototypical Bicyclic Amidine for Studies in Molecular Recognition and Catalysis. M. A. Convery, A. P. Davis, C. J. Dunne, J. W. MacKinnon, J. Chem. Soc. Chem. Commun. 1994, 2557.

(4S,8S)-4,8-Bis(diphenylmethyl)-1,5,7-triazabicyclo[4,4,0]dec-5-ene; A Hindered, Chiral, Bicyclic Guanidine Base with Effective C2-Symmetry. P. H. Boyle, A. P. Davis, K. J. Dempsey, G. D. Hosken, J. Chem. Soc. Chem. Commun. 1994, 1875.

Amide Bond Formation via Pentafluorothiophenyl Active Esters. A. P. Davis, J. J. Walsh, Tetrahedron Lett. 1994, 35, 4865.

Cholic Acid as an Architectural Component in Molecular Recognition Chemistry. NMR and Molecular Mechanics Study of a Tetra-acetoxycholaphane. R. P. Bonar-Law, A. P. Davis, Tetrahedron 1993, 49, 9845.

Cholic Acid as an Architectural Component in Molecular Recognition Chemistry. Synthesis of Cholaphanes with Facial Differentiation of Functionality. R. P. Bonar-Law, A. P. Davis, B. J. Dorgan, Tetrahedron 1993, 49, 9855.

Cholic Acid as an Architectural Component in Molecular Recognition Chemistry. Synthesis of the First Cholaphanes. R. P. Bonar-Law, A. P. Davis, Tetrahedron1993, 49, 9829.

Cholaphanes et al.; Steroids as Structural Components in Molecular Engineering. A. P. Davis, Chem. Soc. Rev. 1993, 22, 243.

An Unexpected Pathway in the Palladium-Catalyzed Chemistry of Allyl Carbonates – the Transfer of Allyloxycarbonyl Groups without Loss of Co2. A. P. Davis, B. J. Dorgan, E. R. Mageean, J. Chem. Soc. Chem. Commun. 1993, 492.

Synthesis of Cyclo-bis[7a,12a,-diacetoxy-3b-dicyanomethyl-3a-(4-methylenephenyl)-cholanamide]; A Cholaphane with Reduced Flexibility and Externally-Directed Functionality. A. P. Davis, M. G. Orchard, J. Chem. Soc., Perkin Trans 1 1993, 919.

Protection of primary amino as pyrrole in organometallic regents. A. P. Davis, T. J. Egan, Tetrahedron Lett. 1992, 33, 8125.

The Stereoselective Addition of Organometallic Reagents to Electron-Deficient Alkylidenecyclohexanes; Alternative Linkages for Cholaphane Synthesis. A. P. Davis, T. J. Egan, M. G. Orchard, D. Cunningham, P. McArdle, Tetrahedron 1992, 48, 8725.

Stereocontrolled Synthesis of Cholic Acid Derivatives with N-Protected 7b- and/or 12b-Amino Substituents. A. P. Davis, M. G. Orchard, Tetrahedron Lett. 1992, 33, 5111.

Super-Acid Catalyzed Addition of Allylsilanes to Carbonyl- Compounds – Synthetic and Mechanistic Aspects. A. P. Davis, M. Jaspars, J. Chem. Soc. Perkin Trans. 11992, 2111.

Diastereo- and Enantio-selective Binding of Octyl Glucosides by a Tetrahydroxycholaphane. K. M. Bhattarai, R. P. Bonar-Law, A. P. Davis, B. A. Murray, J. Chem. Soc. Chem. Commun. 1992, 752.

A Hydrosilylation-Allylation Sequence for the Stereoselective Elaboration of b-Hydroxy Esters. A. P. Davis, S. C. Hegarty, J. Am. Chem. Soc. 1992, 114, 2745.

Catalysis of the Addition of Allyltrimethylsilane to Aldehydes by Silylating Agents; Trimethylsilyl Tetrakis(trifluoromethanesulphonyl)boronate, a New, “Super-silylating” Reagent. A. P. Davis, M. Jaspars, Angew. Chem. Int. Ed. Engl. 1992, 31, 470.

Deprotonation of Nitroalkanes by Bicyclic Amidine and Guanidine Bases; Evidence for Molecular Recognition within a Catalytic Cycle for C-C Bond Formation. P. H. Boyle, M. A. Convery, A. P. Davis, G. D. Hosken, B. A. Murray, J. Chem. Soc. Chem. Commun. 1992, 239.

1,3-Asymmetric Versus 1,2-Asymmetric Induction in the Reduction of Beta-Hydroxy Ketones by Intramolecular Hydrosilylation. S. Anwar, G. Bradley, A. P. Davis, J. Chem. Soc. Perkin Trans. 1 1991, 1383.

Synthesis and X-Ray Crystal-Structure of a New Cholaphane with Externally Directed Functionality. A. P. Davis, M. G. Orchard, A. M. Z. Slawin, D. J. Williams, J. Chem. Soc. Chem. Commun. 1991, 612.

Artificial Receptors for Carbohydrate Derivatives. R. P. Bonar-Law, A. P. Davis, B. A. Murray, Angew. Chem. Int. Ed. Engl. 1990, 29, 1407.

The Benzostabase Protecting Group for Primary Amines – Application to Aliphatic-Amines. R. P. Bonar-Law, A. P. Davis, B. J. Dorgan, M. T. Reetz, A. Wehrsig,Tetrahedron Lett. 1990, 31, 6725.

The Benzostabase Protecting Group for Primary Amines – Application to Aromatic-Amines. R. P. Bonar-Law, A. P. Davis, B. J. Dorgan, Tetrahedron Lett. 1990, 31, 6721.

Superacid Catalysis of the Addition of Allysilanes to Carbonyl- Compounds. A. P. Davis, M. Jaspars, J. Chem. Soc. Chem. Commun. 1990, 1176.

New Procedures for Selectively Protected Cholic-Acid Derivatives – Regioselective Protection of the 12-Alpha-Oh Group, and Tert-Butyl Esterification of the Carboxyl Group. R. P. Bonar-Law, A. P. Davis, J. K. M. Sanders, J. Chem. Soc. Perkin Trans. 1 1990, 2245.

Synthesis of Steroidal Cyclodimers from Cholic Acid; A Molecular Framework with Potential for Recognition and Catalysis. R. P. Bonar-Law, A. P. Davis, J. Chem. Soc. Chem. Commun. 1989, 1050.

The Application of Difunctional Organosilicon Compounds to Organic-Synthesis – 1,3-Asymmetric Induction in the Reduction of Beta-Hydroxy-Ketones. S. Anwar, A. P. Davis, J. Chem. Soc. Chem. Commun. 1986, 831.