A Practical, Large-Scale Synthesis of Pyrene-2-Carboxylic Acid

Juan M. Casas-Solvas, Tiddo J. Mooibroek, Shugantan Sandramurthy, Joshua D. Howgego and Anthony P. Davis*

Synlett, 2014, 25, 2591-2594


Pyrene-2-carboxylic acid is a versatile intermediate for introducing the unusual 2-pyrenyl unit into functional organic molecules. A classical preparation for this molecule has been revised and improved to give a robust and efficient three-step process. The method has been applied on a multigram scale to give pyrene-2-carboxylic acid in >70% overall yield from pyrene.