A Synthetic Lectin for beta-Glucosyl

graphical abstract

N. P. Barwell, M. P. Crump, A. P. Davis*

Angew. Chem. Int. Ed., 2009, 48, 7673-7676


Evolving tastes: Addition of alkoxy groups (green; see picture) to macrotricyclic carbohydrate receptors yields improved affinities and new selectivities. Notably, the propoxy-substituted receptor shows a strong preference for β-glucosyl. Glucose is bound both in water and reconstituted blood plasma, which holds promise for applications in blood glucose monitoring.