Maltodextrin recognition by a macrocyclic synthetic lectin

Patrick Stewart, Charles M. Renney, Tiddo J. Mooibroek, Sadia Ferheena and Anthony P. Davis

Chem. Commun. 2018, 54, 8649-8652.




A monocyclic “temple” synthetic lectin, with extended electron-rich aromatic surfaces, shows enhanced affinities for carbohydrates in water. The methoxy substituents favour binding to α-linked maltodextrins, against the all-equatorial substrates normally favoured by this family of receptors.